Avaliação da patogenicidade de amostras de Brachyspira pilosicoli isoladas de casos de diarréia em suínos

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Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.

Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

La Belgique fédérale après la quatrième réforme de l'état de 1993

info:eu-repo/semantics/publishe

The Rule of Law in the Case Law of the Belgian Constitutional Court

This article provides an overview of the use of the term "rule of law" (rechtsstaat, état de droit) by the Belgian Constitutional Court. As the use of this term turns out to be very limited, it subsequently analyses the Court's jurisprudence on several key features of a State governed by the rule of law, such as the principle of legal certainty, the principle of proportionality. It then describes some current challenges to the rule of law, such as certain absolute obligations under EU law and the fight against terrorism.status: publishe

De verzelfstandiging van bestuurstaken in België. Preadvies voor de Vereniging voor de Vergelijkende Studie van het Recht van België en Nederland

code faculteit: 1.2status: publishe

The Dialogue Between the European Court of Human Rights and Domestic Constitutional Courts: The Belgian Example

status: publishe